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KMID : 0356620090240010042
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Journal of Korean Society of Endocrinology
2009 Volume.24 No. 1 p.42 ~ p.46
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Normal Repetitive Pregnancies and Tumor Regression Induced by Low-Dose Bromocriptine in a Patient with Macroprolactinoma
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Choi Hey-Jung
Park Jin-Yong
Choi Woo-Seok
Song Jong-Gyu
Kim Hee-Young
Seo Ji-A
Kim Sin-Gon
Kim Nan-Hee
Choi Kyung-Mook
Baik Sei-Hyun
Choi Dong-Seop
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Abstract
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Prolactin-secreting adenomas are the most common pituitary tumors. Menstrual disturbances and infertility are the main complaints in women with prolactinoma. Dopaminergic agonists such as bromocriptine are well-established treatments for prolactinoma when pregnancy is desired. Pregnancy-related outcomes in macroprolactinoma are worse than those in microprolactinoma. In addition, symptomatic tumor expansion during pregnancy occurs in 30% of women with macroprolactinoma. Therefore, when women with macroprolactinoma are planning a pregnancy, serum prolactin level should be normalized and the tumor volume significantly reduced. On the other hand, a spontaneous regression of macroprolactinoma can occur after pregnancy. We report a case of macroprolactinoma showing significant tumor regression during repeated pregnancies and low dose bromocriptine treatment, with a literature review.
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KEYWORD
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Bromocriptine, macroprolactinoma, pregnancy
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